What Is ERAD ?
ERAD (Endoplasmic Reticulum-associated Degradation) is a very important cellular survival mechanism that handles problematic proteins in our bodies. Accumulation of misfolded proteins in the Endoplasmic Reticulum (ER) results in ER Stress, which consequently kills healthy cells by initiating apoptosis. ERAD can specifically target misfolded or unfolded proteins such as insulin for degradation. Once a misfolded protein is targeted by the ERAD machinery, it will be removed from the ER and sent to the cytoplasma for degradation by the proteasome. As the cause of ER Stress can be ameliorated, ERAD has been considered a therapeutic target for many diseases.
Pancreatic cell health
Factors that cause serve damages to pancreas function include Endoplasmic Reticulum (ER) Stress, Oxidative Stress, and Inflammation (1, 2). Although the causes of insulin resistance have not been completely clear, scientists believe it is related to body fat and genetics.
ERAD with pancreatic cell health
The all-natural ERAD Plus Pre-D contains specific-component-enriched herbal extracts that have been proven to dramatically ameliorate the damages caused by these bad diet and genetic issues. The effectiveness of these enriched herbal extracts has been documented in research articles, in both animal and human models (3, 4, 5, 6 , 7, 8, 9 and 10)。
With the protection from these herbal extracts, the pancreatic cells can rebuild their strength. As a result, we have better-than-controlled blood sugar levels。
What Can ERAD do for you?
In people with type II diabetes, the insulin-producing β cells and the diabetic medications collaboratively regulate the blood sugar levels.As you may expect over time, to maintain the same level of blood sugar, stronger medications are needed as the β cell mass diminishes.However, the homeostasis (of the β cell mass) is dependent on how fast β cells die.Therefore, in diabetes management, tactics, including enhancing ERAD to reduce ER stress in the β cell should be useful. By doing this, individuals acquire what has been missing in the treatments that are currently available for diabetes. After all, to maintain the same level of blood sugar, the stronger your β cells are, the less medications you need.
